Screening Chemical Libraries

500+  clients worldwide

Prestwick Chemical Customers in the World
350+ publications mentioning the Prestwick Chemical Library®

The Prestwick Chemical Library® is used for:

  • Assay validation
  • Start of a new optimization process
  • Finding of stem cell growth modulators
  • Repurposing /Repositioning

A High Level Of Satisfaction

Clients recontact Prestwick for:

  • Resupply of hits (hit-likeness confirmed)
  • New purchase of Libraries
  • Hit Follow-up services
  • SAR studies and optimization projects

A few examples of Successful application in Drug Repurposing

Old Target / IndicationNew Target / Field
Immunosuppressant Muscular dystrophy (1)
AntibacterialCancer (2)
VasodilatatorFungal infections (3)
CardiotonicNeurodegenerative (and other) diseases (4)                 
Antihypertensive drugAnti-Prions (5)
Antimalarial drugViral infection (6)
VasodilatatorImmune suppression (7)
Neuroleptic, analgesic, antiinflamatory drugCancer (8)
Antimalarial, antihelminthic drugCancer (9)
Antimicrobial, photosensitizerCancer (10)

  1. Gaud A. et al. "Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans". Neuromuscular Disorders, 2004, 14, 365-370.
  2. Yip K. W. et al. "Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen". Clinical Cancer Research, 2006, 12, 5557-5569
  3. Rao F.V. et al. "Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes". Chemistry & Biology, 2005, 12, 973-980
  4. Stoilov et al. "A high throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators". PNAS (2008) 105 (32), 11218-11223
  5. Tribouillard-Tanvier D. "Antihypertensive drug Guanabenz is active in vivo against both yeast and mammalian prions". Plos One (2008), 3(4), 1981.
  6. Porotto M et al. "Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy".  J Virol . (2009),  83(10), 5148-5155
  7. Mulero M.A .et al. "Inhibiting the Calcineurin-NFAT (Nuclear Factor of Activated T Cells) Signaling Pathway with a Regulator of Calcineurin-derived Peptide without Affecting General Calcineurin Phosphatase Activity". The Journal of Biological Chemistry 2009 284(14). 9394–9401
  8. Iorns E et al. Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization Biochem. J. (2009) 417, 361–370
  9. Orzaez M et al. Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL. Bioorganic & Medicinal Chemistry Letters 19 (2009) 1592-1595
  10. Polireddy K. et al. A Novel Flow Cytometric HTS Assay Reveals FunctionalModulators of ATP Binding Cassette Transporter ABCB6 PLoS ONE, 2012, 7, 1-14