Publications

2016

EFMC-ISMC 2016
In silico fragment-based hit identification for efficient discovery of new cosmetic ingredient

RICT 2016
Smart chemical libraries from Prestwick Chemical: powerful tools for high-quality hit discovery

Med. Chem. Commun. 2016, 7, 506-511
Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discovery 

2015

BSI Summer School 2015
CD41 (Itga2b) identifies lymph node lymphatic endothelial cells activated by RANKL

SLAS 2015
The Prestwick Chemical Library®, a valuable tool for screening

WO 2015191799
Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof

WO 2015103489
Heteroatom containing deoxyuridine triphosphatase inhibitors

2014

EFMC-ISMC 2014
Structure-based discovery of novel NIK inhibitors

EFMC-ISMC 2014
Comparison of hit discovery approaches. Case study: NIK inhibitors

EFMC-ISMC 2014
Pharmacophore-based characterization of the Prestwick Chemical Library®

High throughput behevioral sleep assay for larval zebrafish

SfN 2014
In vivo characterization of a novel highly potent GPR88 agonist

SLAS 2014
Screening for neuroprotective activity in a Drosophila model of Parkinson’s disease using a new Prestwick Drosophila library

WO 2014107622
Deoxyuridine triphosphatase inhibitors

WO 2014019023
Alpha7  nicotinic acetylcholine receptor modulators and uses thereof

US 20140088108
2-(3-Aminoaryl) amino-4-aryl-thiazoles and their use as c-Kit inhibitors

2013

Anal. Chem. 2013, 85(18), 8787-8795
Chemical library screening using a SPR-Based inhibition in solution assay: simulations and experimental validation

ANS 2013
BNC375, A novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor, exhibits cognitive enhancement in rodent behavioural models

WO 2013174930
7-Oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

WO 2013057251
Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

WO 2013057253
Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease

WO 2013174931
7-Oxo-4,7 -dihydro- pyrazolo [1,5-a] pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease

2012

WO 2012103583
Positive allosteric modulators of the alpha 7 nicotinic acetylcholine receptor and uses thereof

2011

Eur. J. Org. Chem. 2011, 32, 6409-6412
Expeditious route towards (+/-)-desethyleburnamonine, a precursor of (+/-) Vindeburnol

WO 2011051478
Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors

WO 2011073165
New phenylhydrazone derivatives and their use as pharmaceuticals

2010

WO 2010128163
Small molecule inhibitors of influenza A and B virus and respiratory syncytial virus replication

WO 2010004394
9-Substituted-β-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials

 WO 2010010149
Styrylquinolines, their process of preparation and their therapeutic uses

WO 2010010148
Styrylquinolines, their process of preparation and their therapeutic uses

WO 2010010147
Styrylquinolines, their process of preparation and their therapeutic uses

US 20100113471
2-Aminoaryloxazole compounds as tyrosine kinase inhibitors

Before 2010

CROI 2009
A new quinoline family of HIV-1 integrase inhibitors acting on HIV-1 mutants selected by integrase strand transfer inhibitors

Rencontres Normandes en CBS 2009
New derivatives of 14,15-dihydro-20,21-dinoreburnamin-14-ol as potent antidepressants

WO 2009106967
Novel 7-substituted derivatives of 3-carboxy-oxadiazino-quinolones, preparation thereof and use thereof as anti-bacterial agents

WO 2008001016
Use of a carbonic anhydrase inhibitor for preparation of a drug for treating skeletal muscle degeneration

WO 2007125246
Use of a tricyclic compound for preparing a medicine for treating skeletal muscle degeneration

WO 2007107545
Cyclic-alkylaminederivatives as inhibitors of the interaction between Mdm2 and p53

WO 2007044796
Pyridazinone compounds as calcilytics

WO 2007045758
6-Heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof

WO 2006032631
Inhibitors of the interaction between Mdm2 and p53

WO 2006064375
Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases

WO 2006075012
Novel pyrrolodihydroisoquinolines

WO 2006089815
Novel Pyrrolodihydroisoquinolines as PDE10 inhibitors

WO 2006066070
Prodrug constructs of pyrimidone compounds as calcilytics

WO 2005040139
2-Aminoaryloxazole compounds as tyrosine kinase inhibitors

WO 2005073225
2-(3-Substituted-aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors

WO 2005003129
Pyrrolodihydroisoquinolines as PDE10 inhibitors

WO 2005103047
Derivatives of 14,15-dihydro 20.21-dinoreburnamenin-14-ol, and applications thereof

WO 2005108398
6-Substituted pyridoindolone derivatives production and therapeutic use thereof

WO 2004014903
2-(3-Aminoaryl)amino-4-aryl-thiazoles and their use as c-Kit inhibitors

WO 2004016580
Derivatives of glycinergic R(+)-2-amino-3-hydroxypropanoic acid

WO 2004041817
3-Phenyl substituted pyridoindolone, preparation and their therapeutic use thereof

US 7514454
Piperidin-2,6-dione pamoate salts and their use for the treatment of stress-related affective disorders