PRESTWICK CHEMICAL LIBRARY®

PRESTWICK CHEMICAL LIBRARY (PCL®)

A Recognized Screening Library of 1280 approved drugs

A team of medicinal chemists and pharmacists selected a collection of 1280 off-patent drugs with high chemical and pharmacological diversity, as well as known bioavailability and safety in humans.



PRESTWICK CHEMICALKey features

    PRESTWICK CHEMICAL A unique collection of 1280 off-patent small molecules, 95% approved drugs (FDA, EMA and other agencies)
    PRESTWICK CHEMICAL High chemical and pharmacological diversity
    PRESTWICK CHEMICAL Specially designed to increase potential “high-quality” hits
    PRESTWICK CHEMICAL Over the past 19 years, “hit-likeness” and “hit-workability” have been reported by users in
    PRESTWICK CHEMICAL A constant quality control ensures high purity and stable compounds


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PRESTWICK CHEMICALHow provided?

    PRESTWICK CHEMICAL In DMSO at 10 mM (from 100 µL up to 1 mL) or powder with cherry-picking option

PCL® Premium PCL® Full Premium
Formulation 1280 molecules 1280 molecules
Format 10 mM in DMSO 10 mM in DMSO
Stability 5 years at -20°C 5 years at -20°C
Quantity 100 µL / compound 100 µL / compound
Database Virtual file and USB key
(Excel®, sdf, rdf, db, pdf)
Virtual file and USB key
(Excel®, sdf, rdf, db, pdf
Plate and plate map customization 96 well plates (Greiner)
  • 96 or 384 well plates

  • or CUSTOMER PLATES

  • special mapping possibility
  • Hit follow-up (Expert Med Chem Services) Not included FREE Med Chem assistance:
    Hit classification into chemical families
    / series and analog search
    Hit Re-supply Not included FREE: up to 20 compounds
      PRESTWICK CHEMICAL Always provided with a highly annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file. Annotation includes target, therapeutic class/effect, side effects, patent and AMDET information
      PRESTWICK CHEMICAL Re-supply of any hit-compound up to 100 mg

    PRESTWICK CHEMICALApplications

      PRESTWICK CHEMICAL High-throughput screening (HTS), high-content screening (HCS)
      PRESTWICK CHEMICAL Drug repurposing / Orphan drug
      PRESTWICK CHEMICAL Receptor deorphanization
      PRESTWICK CHEMICAL Assay validation



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    Posters Using PCL®

    at International Meetings

    Prestwick Chemical Library®:

      The Prestwick Chemical Library® (PCL) is Prestwick’s flagship product dedicated to screening. It is a collection of 1280 molecules comprising 100% approved drugs (FDA, EMEA and other agencies) selected for their high chemical and pharmacological diversity. These off-patent drugs have known bioavailability and safety data in humans are available. The PCL was designed to reduce the risk of "low quality" hits and therefor the cost of the initial screening, and appears to be an efficient smart library for hit discovery.

    Prestwick Chemical Library®:

      The ensuing project was designed to optimize the benefits of the PCL®1 through pharmacophore modelling. The pharmacophore characterization of the library was obtained by applying a multi-step approach, first starting with a clustering analysis based RDF pharmacophore similarity. The 1280 compounds of the PCL were found to be clustered in 385 groups: 217 clusters and 168 singletons were obtained. The aim of this work was to generate a model for each cluster and subsequently use these models for extending the PCL and have a pharmacophoric representation of the library. After evaluation on the Zinc 2 database, a random selection of pharmacophore models underwent an external validation process by using DrugBank3 and ChEMBL4 databases.

    Prestwick Chemical Library®:

      PD’s high prevalence (~1 million patients in the US), severe consequencesto the patients’ quality of life and high cost (est. $25 billion pa cost in the US). Both thesereasons make the search for a cure imperative. Traditional target based approaches havenot yet been fruitful. In an alternative approach, we chose to follow a repurposing approachand screen a library of previously safety approved drug compounds for neuroprotectiveactivity against PD using a Drosophila model of the disease.

    Prestwick Chemical Library®:

      Currently we describe a set-up for parallel sleep-wake recording and sleep drug screening in 2304 larval zebrafish.

    smart chemical screening libraries